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任磊

姓名:任磊

职称:教授,博士生导师

电话:0592-2188530

传真:

邮箱:renlei@xmu.edu.cn

个人简历

工作经历:

1990.7-1997.10中国医学科学院生物医学工程研究所实习研究员

2001.6-2003.4新加坡国立大学研究员(research  fellow)

2002.12-2007.7厦门大学医学院副教授

2007年8月-今材料学院教授


教育经历:

1990年天津大学工学学士

1997年中国协和医科大学理学硕士

2001年日本冈山大学哲学博士

      任磊教授,1968年出生,博士,博士生导师。先后毕业于天津大学(学士,1990)、中国协和医科大学(硕士,1997)和日本冈山大学(博士,2001)。2001至2003年在新加坡国立大学材料系从事博士后研究,2003年起任为厦门大学生物医学工程研究中心副教授、厦门大学生物材料系教授。2008年6月至2012年12月担任厦门大学生物材料系副系主任(主持工作);2013年1月起担任厦门大学材料学院副院长。

任磊教授长期从事组织工程支架材料、纳米药物/基因载体方面的研究,近十年来先后承担和参加了多项有关纳米生物材料的科研项目二十多项,包括国家自然科学基金(主持4项)、973计划项目(参与3项等。2004年入选厦门大学首批新世纪优秀人才支持计划;2007年入选福建省新世纪优秀人才支持计划。在Biomaterials、Nanomedicine, Journal of Chemistry、Nanotechnology、Bioconjugate Chemistry等学术刊物上共发表了SCI收录论文50多篇研究论文,论文被引用500多次。荣获2012年度日本セラミックス協会日中セラミックス科学・技術交流奨励賞。受邀参编了Transworld Research Network出版社出版的《Nanostructed Materials for Biomedical Applications》(ISBN: 978-81-7895-397-7)。已获授权中国发明专利6项。是World Journal of Biological Chemistry 杂志的编委及  Biomaterials、Materials Letters等十余个杂志的邀请审稿人。

      任磊教授长期致力于组织工程及药物控制释放等领域的研究,目前主要研究方向包括:(1)构建多功能响应(pH、光、热等刺激感应)的复合材料,探讨在不同靶向生物分子的帮助下,多元纳米结构复合体的对肿瘤细胞/组织的靶向性及跨膜输运效率。(2)构建纳米生物结构复合体系,探讨肿瘤细胞生物微环境的改变与纳米生物复合体中特异性分子的构象变化之间的关系,建立细胞微环境变化与纳米生物复合体中信号强度变化之间的规律性,从而实现对肿瘤细胞识别和诊断。(3)发展新型复合组织工程支架材料,探讨材料-细胞的界面作用。


研究领域

研究领域:

(1) 纳米生物材料的设计与应用

(2) 纳米材料与细胞的相互作用

(3) 纳米仿生材料

(4) 基因释放载体材料

教学领域:

(1) 生物医学材料,生物医学工程专业硕士研究生必修课

(2)组织工程,生物医学工程专业硕士研究生选修课

(3)生物化学实验,本科生课程


主要科研成果


主要代表学术论著与论文

近5年发表的论文:

1.      Shen LH, Bao JF, Wang D, Wang YX, Chen ZW, Ren L*, Zhou X, Ke XB, Chen M, Yang AQ. One-step synthesis of monodisperse, water-soluble ultra-small Fe3O4 nanoparticles for potential bio-application, Nanoscale, 2013; 5: 2133-41.(IF:5.914; JCR 1区)

2.      Shang T, Wang CD, Ren L*, Tian XH, Li DH, Ke XB, Chen M, Yang AQ. Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents. Nanoscale Research Letters 2013; 8:4-12(IF: 2.73; JCR 2区)

3.       Ye SF, Tian MM, Wang TX, Ren L*, Wang D, Shen LH, Shang T. Synergistic Effects of Cell Penetrating Peptide Tat and Fusogenic Peptide HA2 Enhance Cellular Internalization and Gene Transduction of Organosilica Nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine, 2012, 8: 833-841.

 4.       Tu J, Wang TX, Shi W, Wu G, Tian X, Wang Y, Ge D, Ren L*. Multifunctional ZnPc-loaded mesoporous silica nanoparticles for enhancement of photodynamic therapy efficacy by endolysosomal escape. Biomaterials. 2012, 33: 7903-7914.

 5.       Wang D, Ren L*, Zhou X, Wang XZ, Zhou J, Han Y, Kang N. Rapid microwave-enhanced hydrothermal synthesis and shape evolution of uniform NaGdF4:Yb, Er (Tm/Ho) nanocrystals with upconversion and paramagnetic properties. Nanotechnology, 2012, 22: 225705.

 6.       Tian XH, Wei F, Wang TX, Wang D, Wang J, Lin XN, Wang P, Ren L*. Blood–brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin–siloxane nanoparticle. Materials Letter, 2012, 68:94-96. (ISI: 000300480600027).

 7.       Tian XH, Wei F, Wang P, Lin XN, Wang J, Wang D, Ren L. In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain. International Journal of Nanomedicine, 2012, 7: 1031-1041.

 8.       Zhou X, Wang Y, Zhong LB, Bao SG, Han Y, Ren L, Zhang QQ. Rational design of oriented assembly of gold nanospheres with nanorods by biotin–streptavidin connectors. Nanoscale, 2012, 4: 6256-6259.


9.       Zhou X, Shi YF, Ren L, Bao SX, Han Y, Wu SC, Zhang HG, Zhong LB, Zhang QQ. Controllable synthesis, magnetic and biocompatible properties of Fe3O4 and a-Fe2O3 nanocrystals. Journal of Solid State Chemistry. 2012, 196:138–144

10.    Jiang YQ, Ouyang Z, Wang YF, Zhang HG, Kang N, Lin CL, Hou ZQ, Ye SF, Ren L. A molecular basis for enhanced behavior of MC3T3-E1 cells on poly(lactic-co-glycolic acid)-multi-wall carbon nanotubes nanocomposite. Current Nanoscience, 2012, 8: 587-597.

 11.    Shen LH, Shang T, Zhou J, Wang W, Han Y, Ren L. One-pot synthesis of water soluble, extremely small-sized superparamagnetic magnetite nanoparticles. Advanced Materials Research 2012, 531: 219-222.

 12.    Tian XH, Lin XN, Wei F, Feng W, Huang ZC, Wang P, Ren L, Diao Y. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles. International Journal of Nanomedicine, 2011, 6: 445-452. (ISI: 000288248900047).

 13.    Zhao XQ, Wang TX, Liu W, Wang CD, Wang D, Shang T, Shen LH, Ren L*. Multifunctional Au@IPN-pNIPAAm nanogels for cancer cell imaging and combined chemo-photothermal treatment. J Mater Chem, 2011, 21: 7240–7247. (ISI: 000290167200028).

 14.    YN Sun, CD Wang, XM Zhang, Ren L*, XH Tian. Shape dependence of gold nanoparticles on in vivo acute toxicological effects and biodistribution. J Nanosci & Nanotech, 2011, 11: 1210-1216. (ISI: 000287167900043).

 15.    Sun LP, Zhang ZW, Zhang JF, Li H, Ren L, Weng J, Zhang QQ. Interation of gold nanoparticles with DNA and applications in biomedicine. In: “Nanostructed materials for biomedical applications”, Tan MC, Chow GM, Ren L (Eds), Transworld Research Network, 2010,243-264. (ISBN: 978-81-7895-397-7).

 16.    Ren L*, Wang J, Yang FY, Wang L, Wang D, Wang TX, Tian MM. Fabrication of gelatin–siloxane fibrous mats via sol–gel and electrospinning procedure and its application for bone tissue engineering. Mat Sci Eng C, 2010, 30: 437-444. (ISI: 000276590000017).

 17.    Yin P, Wang J, Ren L*, Wang ZY, Wang TX, Tian MM, Wang D, Tian XH. Conjugation of membrane-destabilizing peptide onto gelatin–siloxane nanoparticles for efficient gene expression. Mat Sci Eng C, 2010, 30: 1260-1265. (ISI: 000282905600026).

 18.    Tan MC, Chow GM, Ren L, Zhang QQ. Inorganic nanoparticles for biomedical applications, In: “NanoScience in Biomedicine”, Shi DL (Eds), Qinghua University Press, 2009, 272-289. (ISBN: 978-7-302-1705-4).

 19.    Ge DT, Wu DW, Wang ZY, Shi W*, Wu T, Zhang AF, Hong SM, Wang J, Zhang Y, Ren L*. Cellular Uptake Mechanism of Molecular Umbrella. Bioconjugate Chem, 2009, 20, 2311–2316. (ISI: 000272690100014).

 20.    Zhang YF, Yin P, Zhao XQ, Wang J, Wang J, Wang CD, Ren L*, Zhang QQ. O-Carboxymethyl-chitosan/organosilica hybrid nanoparticles as non-viral vectors for gene delivery. Mat Sci Eng C, 2009, 29: 2045-2049. (ISI: 000269140200045).

 21.    Sun LP, Zhang ZW, Wang S, Zhang JF, Li H, Ren L, Weng J, Zhang QQ. Effect of pH on the interaction of gold nanoparticles with DNA and application in the detection of human p53 gene mutation. Nanoscale Res Lett, 2009, 4: 216-220. (ISI: 000263173400005).

 22.    Xu Y, Jiang J, Lu Y, Sun RJ, Song JM, Ren L, Yu SH. Facile surfactant-free synthesis of water-dispersible willow-leaf-like carbonate apatite nanorods in ethanol/water mixed solution and their cytotoxicity. Crystal Growth & Design, 2008, 8, 3822-3828. (ISI: 000259672900058).

 23.    Wang ZY, Zhao Y, Ren L*, Jin LH, Sun LP, Yin P, Zhang YF and Zhang QQ. Novel gelatin–siloxane nanoparticles decorated by Tat peptide as vectors for gene therapy. Nanotechnology, 2008, 19, 445103 (14pp). (ISI: 000259701800003).

 24.    Guo Y, Shi DL, Cho HS, Dong ZY, Kulkarni A, Pauletti GM, Wang W, Lian J, Liu W, Ren L, Zhang QQ, Liu GK, Huth C, Wang LM, Ewing RC. In vivo Imaging and Drug Storage by Quantum-Dot-Conjugated Carbon Nanotubes, Adv Funct Mater, 2008, 18: 2489-2497. (ISI: 000259521600005).

 25.    Zhao Y, Yin P, Wang ZY, Ren L*, Zhang QQ. Novel organic-inorganic hybrid nanoparticles as non-viral gene vector. Adv Mater Res, 2008, 47-50: 1319-1322. (ISI: 000258807900324).

 26.    Liu W, Wang ZY, Yin P, Ren L*, Zhang QQ. Near-IR sensitive Au-Au2S nanoparticles with biocompatibility for drug delivery. Adv Mater Res, 2008, 47-50: 1315-1318. (ISI: 000258807900323).

 27.    Wang L, Yu B, Ren L*, Sun LP, Zhang QQ. Microsphere-integrated gelatin-siloxane hybrid scaffolds for bone tissue engineering: in vitro bioactivity & antibacterial activity. Front Mater Sci China, 2008, 2: 172-178.

 28.    Huang XL, Zhang B, Ren L*, Ye SF, Sun LP, Zhang QQ, Tan MC, Chow GM. In vivo Toxic Studies and Biodistribution of NIR Sensitive Au-Au2S Nanoparticles as Potential Drug Delivery Carriers. J Mater Sci: Mater in Med, 2008, 19: 2581-2588. (ISI: 000255879100009).

 29.    Ren L*, Huang XL, Zhang B, Sun LP, Zhang QQ, Tan MC, Chow GM. Cisplatin Loaded Au-Au2S Nanoparticles for Potential Cancer Therapy: Cytotoxicity, In Vitro Carcinogenicity, and Cellular Uptake. J Biomed Mater Res A, 2008, 85A: 787-796. (ISI: 000255530500026).

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