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石巍

姓名:石巍

职称:教授

电话:0592-2188502

传真:0592-2188502

邮箱:shiwei@xmu.edu.cn

个人简历

教育经历:

2000.9-2003.3 天津大学化工学院化学工程专业博士研究生

1998.9-2001.3 天津大学化工学院生物医学工程专业硕士研究生

1990.9-1994.7吉林化工学院学士      

      2003年毕业于天津大学,工学博士,厦门大学第六批青年骨干教师,2012年先后入选福建省高校新世纪优秀人才和教育部新世纪优秀人才,现为厦门大学材料学院生物材料系教授。主持和参加过国家自然科学基金、 “ 十五”攻关、福建省重大科技计划项目、福建省自然科学基金和厦门市科技计划等项目。发表论文60余篇,其中50余篇被SCI和EI收录,作为第一发明人获得发明专利授权7项。


研究领域

(1)药物释放

(2)膜式人工器官

(3)生物传感器

(4)智能生物材料


主要科研成果

1.设计出一类能有效屏蔽光敏剂聚集、显著增强光动力治疗的光动力药物载体。

2.构建了一系列具有导电性能的人工器官膜,该膜在电刺激条件下展现了良好的血液相容性和血液净化能力。

3.利用CuO和Cu2O的协同作用构建了一种具有高灵敏度、宽检测范围、低检测限的生物传感器。

主要代表学术论著与论文

1. F.Q. Meng, W. Shi*, Y.N. Sun, X. Zhu, G.S. Wu, C.Q. Ruan, X. Liu, D.T. Ge, Nonenzymatic biosensor based on CuxO nanoparticles deposited on polypyrrole nanowires for improving detection range, Biosensors & Bioelectronics, 2013, 42: 141–147

2. C.Q. Ruan, W. Shi*, H.R. Jiang, Y.N. Sun*, X. Liu, D.T. Ge, One-pot preparation of glucose biosensor based on polydopamine-graphene composite film modified enzyme electrode, Sensors & Actuators B, 2013, 177: 826–832

3. J. Wang, G.S. Wu, W. Shi*, X. Liu, C.Q. Ruan, M.Q. Xue, D.T. Ge, Affinity electromembrane with covalently coupled heparin for thrombin adsorption, Journal of Membrane Science, 2013, 428: 70–77

4. M.Q. Xue, Y.S. Ling, G.S. Wu, X. Liu, D.T. Ge, W. Shi*, Surface-modified anodic aluminum oxide membrane with hydroxyethyl celluloses as a matrix for bilirubin removal, Journal  of  Chromatography B, 2013, 912: 1–7

5. J. Tu, T.X. Wang, W. Shi*, G.S. Wu, X.H. Tian, Y.H. Wang, D.T. Ge, L. Ren, Multifunctional ZnPc-loaded mesoporous silica nanoparticles for enhancement of photodynamic therapy efficacy by endolysosomal escape, Biomaterials, 2012, 33: 7903–7914

6. H.R. Jiang, A.F. Zhang, Y.A. Sun, X.N. Ru, D.T. Ge, W. Shi*, Poly(1-(2-carboxyethyl)pyrrole)/polypyrrole composite nanowires for glucose biosensor, Electrochimica Acta, 2012, 70: 278–285

7. C.F. Song, A.F. Zhang, W. Shi*, H.R. Jiang, D.T. Ge, Functionalized silica nanotubes as affinity matrices for bilirubin removal, IEEE Transactions on Nanotechnology, 2011, 10: 626–631

8. J. Wang, W. Shi*, H.R. Jiang, G.S. Wu, C.Q. Ruan, D.T. Ge, Heparin-doped affinity electromembranes for thrombin purification, Journal of Membrane Science, 2011, 373: 89–97

9. C.F. Song, W. Shi*, H.R. Jiang, J. Tu, D.T. Ge, pH-sensitive characteristics of poly(acrylic acid)-functionalized anodic aluminum oxide (AAO) membranes, Journal of Membrane Science, 2011, 372: 340–345

10. W. Shi*, Y.Y. Ma, C.F. Song, H.R. Jiang, X.N. Ru, J. Tu, S.H. Jiang, J. Wang, D.T. Ge, Affinity electromembrane: electrically facilitated adsorption, Journal of Membrane Science, 2010, 354: 86–92

11. W. Shi*, H.H. Cao, C.F. Song, H.R. Jiang, J. Wang, S.H. Jiang, J. Tu, D.T. Ge, Poly(pyrrole-3-carboxylic acid)–alumina composite membrane for affinity adsorption of bilirubin, Journal of Membrane Science, 2010, 353: 151–158

12. W. Shi*, Y.Q. Shen, H.R. Jiang, C.F. Song, Y.Y. Ma, J. Mu, B.Y. Yang, D.T. Ge, Lysine-attached anodic aluminum oxide (AAO)–silica affinity membrane for bilirubin removal, Journal of Membrane Science, 2010, 349: 333–340

13. D.T. Ge, D.W. Wu,  Z.Y. Wang,  W. Shi*, T. Wu, A.F. Zhang, S.M. Hong,  J. Wang, Y. Zhang, L. Ren, Cellular uptake mechanism of molecular umbrella, Bioconjugate Chemistry, 2009, 20: 2311–2316

14. D.T. Ge*, X.D. Tian, R.C. Qi, S.Q. Huang, J. Mu, S.M. Hong, S.F. Ye, X.M. Zhang, D.H. Li, W. Shi*, A polypyrrole-based microchip for controlled drug release, Electrochimica Acta, 2009, 55: 271–275

15. D.T. Ge*, S.Q. Huang, R.C. Qi, J. Mu, Y.Q. Shen, W. Shi*, Nanowire-based polypyrrole hierarchical structures synthesized by a two-step electrochemical method, Chemphyschem, 2009, 10: 1916–1921(cover picture)

16. W. Shi*, H.H. Cao, Y.Q. Shen, C.F. Song, D.H. Li, Y. Zhang*, D.T. Ge*, Chemically modified PPyCOOH microtubes as an affinity matrix for protein purification, Macromolecular Chemistry and Physics, 2009, 210: 1379–1386

17. W. Shi*, Q.Y. Shen, D.T. Ge*, M.Q. Xue, H.H. Cao, S.Q. Huang, J.X. Wang, G.L. Zhang, F.B. Zhang, Functionalized anodic aluminum oxide (AAO) membranes for affinity protein separation, Journal of Membrane Science, 2008, 325: 801–808

18. W. Shi, P.F. Liang, D.T. Ge*, J.X. Wang, Q.Q. Zhang, Starch-assisted synthesis of polypyrrole nanowires by a simple electrochemical approach, Chemical Communications, 2007, 2414–2416

19. D.T. Ge, W. Shi*, L. Ren, F.B. Zhang, G.L. Zhang, X.B. Zhang, Q.Q. Zhang, Variation analysis of affinity-membrane model based on Freundlich adsorption, Journal of Chromatography A, 2006, 1114: 40–44

20. W. Shi, D.T. Ge*, J.X. Wang, Z.Z Jiang, L. Ren, Q.Q. Zhang, Heparin-controlled growth of polypyrrole nanowires, Macromolecular Rapid Communications, 2006, 27: 926–930

21. D.T. Ge, D.W. Wu, W. Shi*, Y.Y. Ma, X.D. Tian, P.F. Liang, Q.Q Zhang, An albumin-fixed membrane for the removal of protein-bound toxins, Biomedical Materials, 2006, 1: 170–174

22. D.T. Ge, W. Shi*, L. Ren, Q.Q Zhang, Removal of bilirubin by albumin-fixed polysulfone membrane, Materials Science Forum, 2006, 510-511: 682–685

23. W. Shi*, F.B. Zhang, G.L. Zhang, Mathematical analysis of affinity membrane chromatography, Journal of Chromatography A, 2005, 1081: 156–162

24. W. Shi*, F.B. Zhang, G.L. Zhang, Adsorption of bilirubin with polylysine carrying chitosan-coated nylon affinity membranes, Journal of Chromatography B, 2005, 819: 301–306

25. W. Shi*, F.B. Zhang, G.L. Zhang, D.T. Ge, Q.Q. Zhang, Adsorption of bilirubin on poly-L-lysine-containing nylon membranes: applications in affinity chromatography, Polymer International, 2005, 54: 790–795

26. W. Shi, F.B. Zhang, G.L. Zhang, Preparation of chitosan-coated nylon membranes and their application as affinity membranes, Chinese Chemical Letters, 2005, 16: 1085–1088

27. W. Shi*, F.B. Zhang, G.L. Zhang, L.Q. Jiang, S.L. Wang, H. Xu, Facilitated transport of lipophilic toxins through polysulfone membrane using albumin as a carrier, Molecular Simulation, 2004, 30: 117–120

28. W. Shi*, F.B. Zhang, G.L. Zhang, L.Q. Jiang, Y.J. Zhao, S.L. Wang, Polylysine-immobilized affinity nylon membrane used for bilirubin adsorption, Molecular Simulation, 2003, 29: 787–790 


授权发明专利:

1. 石巍, 沈雨青, 葛东涛, 马媛媛, 吴德旺, 张其清, 亲和性的壳聚糖-氨基硅烷-阳极氧化铝复合膜的制备方法, 专利号: ZL 200810071236.9

2. 石巍, 沈雨青, 葛东涛, 张其清, 亲和性的明胶-氨基硅烷-阳极氧化铝复合膜的制备方法, 专利号: ZL 200710009962.3

3. 石巍, 曹慧慧, 葛东涛, 张其清, 用作亲和吸附介质的聚N-2-羧乙基吡咯金属螯合纳米管的制备方法, 专利号: ZL 200810071229.9

4. 石巍, 马媛媛, 葛东涛, 张其清, 固载辛巴蓝的聚吡咯-聚碳酸酯复合膜的制备方法, 专利号: ZL 200710009324.1

5. 石巍, 张凤宝, 张国亮, 亲和性聚砜—羟乙基纤维素复合非对称超滤膜的制备方法, 专利号: ZL02153350.4

6. 石巍, 张凤宝, 张国亮, 王淑兰, 亲和性的聚砜—壳聚糖复合非对称超滤膜的制备方法, 专利号: ZL02130927.2

7. 石巍, 张凤宝, 张国亮, 王淑兰, 用于亲和微滤的尼龙—壳聚糖复合膜的制备方法, 专利号: ZL 02130926.4

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