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侯振清

姓名:侯振清

职称:教授

电话:0592-2189650(实验室)

传真:0592-2183937

邮箱:houzhenqing@xmu.eud.cn

个人简历

研究工作经历:

1985/08-1990/10,山东新泰市人民医院,制剂室,药师;

1994/08-1996/07,山东鲁抗制药股份有限公司,研发部,工程师;

1996/08-1999/08,济宁市第一医院,制剂中心主任,主管药师;

1999/08-2000/08,西安交通大学,生物医学工程研究所,访问学者;

2005/04-至今,厦门大学材料学院生物材料系、厦门大学生物仿生与软物质研究院,教授(2005.4-2010.8讲师,2010.9-2014.8副教授,2014.8-至今 教授)。

教育经历:

1981/09-1985/07,山东大学,药学系药学专业,学士;

1991/09-1994/07,中国药科大学,生物技术学院生化制药专业,硕士;

2000/09-2004/06,西安交通大学,生物医学工程研究所,生物医学工程专业,博士。


研究领域

主要从事药物控缓释制剂及生物材料方面的研究工作,近年来重点研究方向为抗肿瘤药物控缓释和骨折材料的研究。


主要科研成果

主持和参与了国家973项目1项,国家支撑计划项目1项,多项国家自然科学基金,多项厦门市科技计划项目;另外,与企业和医院横向合作项目4项。研究成果先后在Journal of Controlled Release,Chemical Science, Mol. Pharmoceutics等杂志上发表论文40多篇。

主要代表学术论著与论文

[1] Jia Mengmeng, Li Yang, Yang Xiangrui, Huang Yuancan, Wu Hongjie, Huang Yu, Lin Jinyan, Li Yanxiu, Hou Zhenqing, Zhang Qiqing. Development of Both Methotrexate and Mitomycin C Loaded PEGylated Chitosan Nanoparticles for Targeted Drug Codelivery and Synergistic Anticancer Effect[J]. ACS Appl. Mater. Interfaces, 2014, 6: 11413-11423.

[2] Li Yang, Lin Jinyan, Huang Yu, Li Yanxiu, Yang Xiangrui, Wu Hongjie, Wu Shichao, Xie Liya, Dai Lizong, Hou Zhenqing. Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells[J]. ACS Appl. Mater. Interfaces, 2015, 7: 25553-25559.

[3] Li Yang, Lin Jinyan, Yang Xiangrui, Li Yanxiu, Wu Shichao, Huang Yu, Ye Shefang, Xie Liya, Dai Lizong, Hou Zhenqing. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release[J]. ACS Appl. Mater. Interfaces, 2015, 7: 17573-17581.

[4] Lin Jinyan, Li Yang, Li Yanxiu, Wu Hongjie, Yu Fei, Zhou Shuifan, Xie Liya, Luo Fanghong, Lin Changjian, Hou Zhenqing. Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging[J]. ACS Appl. Mater. Interfaces, 2015, 7: 11908-11920.

[5] Li Yang, Lin Jinyan, Wu Hongjie, Jia Mengmeng, Yuan Conghui, Chang Ying, Hou Zhenqing, Dai Lizong. Novel Methotrexate Prodrug-Targeted Drug Delivery System Based on PEG-Lipid-PLA Hybrid Nanoparticles for Enhanced Anticancer Efficacy and Reduced Toxicity of Mitomycin C[J]. J. Mater. Chem. B, 2014, 2: 6534-6548.

[6] Lin Jinyan, Li Yanxiu, Li Yang, Cui Fei, Yu Fei, Wu Hongjie, Xie Liya, Luo Fanghong, Hou Zhenqing, Lin Changjian. Self-Targeted, Bacillus-Shaped, and Controlled-Release Methotrexate Prodrug Polymeric Nanoparticles for Intratumoral Administration with Improved Therapeutic Efficacy in Tumor-Bearing Mice[J]. J. Mater. Chem. B, 2015, 3: 7707-7717.

[7] Cui Fei, Lin Jinyan, Li Yang, Li Yanxiu, Wu Hongjie, Yu Fei, Jia Mengmeng, Yang Xiangrui, Wu Shichao, Xie Liya, Ye Shefang, Luo Fanghong, Hou Zhenqing. Bacillus-Shape Design of Polymer Based Drug Delivery Systems with Janus-Faced Function for Synergistic Targeted Drug Delivery and More Effective Cancer Therapy[J]. Mol. Pharmaceutics, 2015, 12: 1318-1327.

[8] Hou Zhenqing, Li Yang, Huang Yuancan, Zhou Chunxiao, Lin Jinyan, Wang Yixiao, Cui Fei, Zhou Shuifan, Jia Mengmeng, Ye Shefang, Zhang Qiqing. Phytosomes Loaded with Mitomycin C-Soybean Phosphatidylcholine Complex Developed for Drug Delivery[J]. Mol. Pharmaceutics, 2013, 10: 90-101.

[9] Li Yang, Lin Jinyan, Wu Hongjie, Chang Ying, Yuan Conghui, Liu Cheng, Wang Shuang, Hou Zhenqing, Dai Lizong. Orthogonally Functionalized Nanoscale Micelles for Active Targeted Codelivery of Methotrexate and Mitomycin C with Synergistic Anticancer Effect[J]. Mol. Pharmaceutics, 2015, 12: 769-782.

[10] Li Yang, Wu Hongjie, Jia Mengmeng, Cui Fei, Lin Jinyan, Yang Xiangrui, Wang Yange, Dai Lingfeng, Hou Zhenqing. Therapeutic Effect of Folate-Targeted and PEGylated Phytosomes Loaded with a Mitomycin C-Soybean Phosphatidyhlcholine Complex[J]. Mol. Pharmaceutics, 2014, 11: 3017-3026.

[11] Li Yang, Wu Hongjie, Yang Xiangrui, Jia Mengmeng, Li Yanxiu, Huang Yu, Lin Jinyan, Wu Shichao, Hou Zhenqing. Mitomycin C-Soybean Phosphatidylcholine Complex-Loaded Self-Assembled PEG-Lipid-PLA Hybrid Nanoparticles for Targeted Drug Delivery and Dual-Controlled Drug Release[J]. Mol. Pharmaceutics, 2014, 11: 2915-2927.

[12] Zhou Shuifan, Li Yang, Cui Fei, Jia Mengmeng, Yang Xiangrui, Wang Yange, Xie Liya, Zhang Qiqing, Hou Zhenqing. Development of Multifunctional Folate-Poly(Ethylene Glycol)-Chitosan-Coated Fe3O4 Nanoparticles for Biomedical Applications[J]. Macromol. Res., 2014, 22: 58-66.

[13] Cui Fei, Li Yang, Zhou Shuifan, Jia Mengmeng, Yang Xiangrui, Yu Fei, Ye Shefang, Hou Zhenqing, Xie Liya. A Comparative in Vitro Evaluation of Self-Assembled PTX-PLA and PTX-MPEG-PLA Nanoparticles[J]. Nanoscale Res. Lett., 2013, 8: 301.

[14] Hou Zhenqing, Wang Yixiao, Shen Lihua, Guo Hao, Wang Gongxin, Li Yang, Zhou Shuifan, Zhang Qiqing, Jiang Qian. Synthesis of Dumbbell-Like ZnO Microcrystals Via a Simple Solution Route[J]. Nanoscale Res. Lett., 2012, 7: 507.

[15] Hou Zhenqing, Zhan Chuanming, Jiang Qiwei, Hu Quan, Li Le, Chang Di, Yang Xiangrui, Wang Yixiao, Li Yang, Ye Shefang, Xie Liya, Yi Yunfeng, Zhang Qiqing. Both FA- and mPEG-Conjugated Chitosan Nanoparticles for Targeted Cellular Uptake and Enhanced Tumor Tissue Distribution[J]. Nanoscale Res. Lett., 2011, 6: 563.

[16] Luo Fanghong, Li Yang, Jia Mengmeng, Cui Fei, Wu Hongjie, Yu Fei, Lin Jinyan, Yang Xiangrui, Hou Zhenqing, Zhang Qiqing. Validation of a Janus Role of Methotrexate-Based PEGylated Chitosan Nanoparticles in Vitro[J]. Nanoscale Res. Lett., 2014, 9: 363.

[17] Yang Xiangrui, Wu Shichao, Wang Yange, Li Yang, Chang Di, Luo Ying, Ye Shefang, Hou Zhenqing. Evaluation of Self-Assembled HCPT-Loaded PEG-B-PLA Nanoparticles by Comparing with HCPT-Loaded PLA Nanoparticles[J]. Nanoscale Res. Lett., 2014, 9: 2408.

[18] Yi Yunfeng, Li Yang, Wu Hongjie, Jia Mengmeng, Yang Xiangrui, Wei Heng, Lin Jinyan, Wu Shichao, Huang Yu, Hou Zhenqing, Xie Liya. Single-Step Assembly of Polymer-Lipid Hybrid Nanoparticles for Mitomycin C Delivery[J]. Nanoscale Res. Lett., 2014, 9: 560.

[19] Yi Yunfeng, Zhang Ying, Wang Yixiao, Shen Lihua, Jia Mengmeng, Huang Yu, Hou Zhenqing, Zhuang Guohong. Ethylenediaminetetraacetic Acid as Capping Ligands for Highly Water-Dispersible Iron Oxide Particles[J]. Nanoscale Res. Lett., 2014, 9: 1-7.

[20] Hou Zhenqing, Lin Jinyan, Li Yanxiu, Guo Fuqiang, Yu Fei, Wu Hongjie, Fan Zhongxiong, Zhi Lili, Luo Fanghong. Validation of a Dual Role of Methotrexate-Based Chitosan Nanoparticles in Vivo[J]. RSC Adv., 2015, 5: 41393-41400.

[21] Lin Jinyan, Li Yang, Wu Hongjie, Yang Xiangrui, Li Yanxiu, Ye Shefang, Hou Zhenqing, Lin Changjian. Tumor-Targeted Co-Delivery of Mitomycin C and 10-Hydroxycamptothecin Via Micellar Nanocarriers for Enhanced Anticancer Efficacy[J]. RSC Adv., 2015, 5: 23022-23033.

[22] Hou Zhenqing, Zhou Chunxiao, Luo Ying, Zhan Chuanming, Wang Yixiao, Xie Liya, Zhang Qiqing. PLA Nanoparticles Loaded with an Active Lactone Form of Hydroxycamptothecin: Development, Optimization, and in Vitro–in Vivo Evaluation in Mice Bearing H22 Solid Tumor[J]. Drug Develop. Res., 2011, 72: 337-345.

[23] Hou Zhenqing, Li Le, Zhan Chuanming, Zhu Peijuan, Chang Di, Jiang Qiwei, Ye Shefang, Yang Xiangrui, Li Yang, Xie Liya, Zhang Qiqing. Preparation and in Vitro Evaluation of an Ultrasound-Triggered Drug Delivery System: 10-Hydroxycamptothecin Loaded PLA Microbubbles[J]. Ultrasonics, 2012, 52: 836-841.

[24] Yang Xiangrui, Wu Shichao, Li Yang, Huang Yu, Lin Jinyan, Chang Di, Ye Shefang, Xie Liya, Jiang Yuan, Hou Zhenqing. Integration of an Anti-Tumor Drug into Nanocrystalline Assemblies for Sustained Drug Release[J]. Chem. Sci., 2015, 6: 1650-1654.

[25] Wang Yixiao, Hou Zhenqing, Guo Hao, Shen Lihua, Wang Gongxin, Cui Fei, Zhang Qiqing. Preparation of ZnO Nanorods Via Aqueous Solution Process and Their Pl Properties[J]. Mater. Lett., 2013, 91: 107-110.

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