From uncontrollability to controllabilityOpportunities and challenges of printing technologies in guided cellular responses
Hongjun Wang, PhD, Biomedical Engineering, Chemistry and Biological Sciences, Stevens Institute of Technology
Abstract: Maintenance of desired cell phenotype is always essential toward functional tissue regeneration, which is at least equally if not more important when it comes to in vitro creation of implantable tissue constructs. Increasing evidence has demonstrated that in tissue engineering the scaffolds not only provide the cells with a temporary support for attachment and growth, but also instruct the cells for their fate. In contrast to tremendous knowledge base on the effect of biochemical factors, limited understanding has been made in correlating the physical characteristics of scaffolds with cellular responses. In this regard, there is a great need to encode the regulatory effect of physical features of scaffolds on cell phenotypic expression, which can better guide the scaffold design for functional tissue formation. Ideally, tissue-engineering scaffolds should maximally recapture the physicochemical properties of native tissues. The establishment of a variety of new fabrication technologies such as electrospinning, 3D writing and inkjet printing offers us versatile capabilities of incorporating the hierarchical and complex features of native extracellular matrix (ECM), especially on a micro/nanoscale, into scaffold design. This talk will summarize the recent scaffold fabrication technologies developed in our lab and then elaborate their potential utility in fabrication of multiscale biomimetic scaffolds to regulate the cellular responses and tissue formation.
Dr. Hongjun Wang is Associate Professor of Biomedical Engineering and Associate Professor of Chemistry and Chemical Biology at the Stevens Institute of Technology, Hoboken, New Jersey, USA. The research interests of the Wang lab (www.stevens.edu/wanglab) mainly focus on multiscale biomimetic materials design, tissue reconstruction, in vitro tissue-on-a-chip and nanomedicine. His group has contributed a dozen of book chapters and invited reviews, a number of patent applications, over 100 invited talks and seminars and about 70 peer-reviewed papers in Advanced Materials, ACS Nano and Biomaterials. His work has been well cited (H index=25). He is also a recipient of several awards including Jess N. Davis Award for Excellent Research (2015), Jess N. Davis Award for Exemplary Research (2010), etc. Prior to joining Stevens, he was a research fellow at the Wellman Center for Photomedicine, Massachusetts General Hospital and the Department of Dermatology, Harvard Medical School, Boston. Dr. Wang received his 1st Doctorate in Polymer Chemistry & Physics (Prof. Binglin He, 1998) with honors from the Institute of Polymer Chemistry, Nankai University, Tianjin, China. He then worked at a Dutch biomedical company, IsoTis NV, and received his 2nd Doctorate in Biomedical Engineering with Prof. dr. Clemens van Blitterswijk from the Institute for Biomedical Technology, University of Twente, Netherlands in 2003. His research has been well funded by NIH, NSF and other agencies.