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From uncontrollability to controllabilityOpportunities and challenges of printing technologies in guided cellular responses
发布时间: 2016-06-13
浏览次数: 16

题目:

From uncontrollability to controllabilityOpportunities and  challenges of printing technologies in guided cellular responses

讲座人:

Hongjun Wang, PhD, Biomedical Engineering, Chemistry and  Biological Sciences, Stevens Institute of Technology

时间:

2016年6月20日上午8:30-10:00

地点:

凌峰楼401会议室

内容:

Abstract: Maintenance of desired cell  phenotype is always essential toward functional tissue regeneration, which is at  least equally if not more important when it comes to in vitro creation of  implantable tissue constructs. Increasing evidence has demonstrated that in  tissue engineering the scaffolds not only provide the cells with a temporary  support for attachment and growth, but also instruct the cells for their fate.  In contrast to tremendous knowledge base on the effect of biochemical factors,  limited understanding has been made in correlating the physical characteristics  of scaffolds with cellular responses. In this regard, there is a great need to  encode the regulatory effect of physical features of scaffolds on cell  phenotypic expression, which can better guide the scaffold design for functional  tissue formation. Ideally, tissue-engineering scaffolds should maximally  recapture the physicochemical properties of native tissues. The establishment of  a variety of new fabrication technologies such as electrospinning, 3D writing  and inkjet printing offers us versatile capabilities of incorporating the  hierarchical and complex features of native extracellular matrix (ECM),  especially on a micro/nanoscale, into scaffold design. This talk will summarize  the recent scaffold fabrication technologies developed in our lab and then  elaborate their potential utility in fabrication of multiscale biomimetic  scaffolds to regulate the cellular responses and tissue formation.

Dr.  Hongjun Wang is Associate Professor of Biomedical Engineering and Associate  Professor of Chemistry and Chemical Biology at the Stevens Institute of  Technology, Hoboken, New Jersey, USA. The research interests of the Wang lab (www.stevens.edu/wanglab) mainly focus  on multiscale biomimetic materials design, tissue reconstruction, in  vitro tissue-on-a-chip and nanomedicine. His group has contributed a dozen  of book chapters and invited reviews, a number of patent applications, over 100  invited talks and seminars and about 70 peer-reviewed papers in Advanced  Materials, ACS Nano and Biomaterials. His work has been well cited  (H index=25). He is also a recipient of several awards including Jess N. Davis  Award for Excellent Research (2015), Jess N. Davis Award for Exemplary Research  (2010), etc. Prior to joining Stevens, he was a research fellow at the Wellman  Center for Photomedicine, Massachusetts General Hospital and the Department of  Dermatology, Harvard Medical School, Boston. Dr. Wang received his  1st Doctorate in Polymer Chemistry & Physics (Prof. Binglin He,  1998) with honors from the Institute of Polymer Chemistry, Nankai University,  Tianjin, China. He then worked at a Dutch biomedical company, IsoTis NV, and  received his 2nd Doctorate in Biomedical Engineering with Prof. dr.  Clemens van Blitterswijk from the Institute for Biomedical Technology,  University of Twente, Netherlands in 2003. His research has been well funded by  NIH, NSF and other agencies.


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