报告题目：Nanoparticle Exploration of Tumor Microenvironment in Desmoplastic Cancer
报告摘要：The thick stroma in desmoplastic tumor such as pancreatic cancer supports tumor growth and presents a difficult barrier for drug delivery. Tumor associated fibroblasts, not cancer cells, are the major cells taken up the nanoparticles administered through the blood. We take advantage of the “off targeting” effect to deliver genes and drugs to remodel the TME. The therapeutic potential of the approach will be discussed.
报告人简介：Leaf Huang, Ph.D. is the Fred Eshelman Distinguished Professor, Division of Pharmacoengineering and Molecular Pharmaceutics in the Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Dr. Huang’s research has been in the area of gene therapy and targeted drug delivery. He has pioneered the liposome non-viral vector and has designed and manufactured the cationic lipid vector for the first non-viral clinical trial in 1992. His current work centers on nanoparticle vectors for gene transfer in tumor and liver. He also continues research in establishing a ligand targeted delivery system for cDNA, mRNA, siRNA, proteins and peptides for tumor growth inhibition and for vaccines in treating cancers.He has authored or co-authored more than 500 papers with an H-index of 113. He is also the inventor or co-inventor of 21 US and foreign patents. In 2004, he received the Alec D. Bangham MD FRS Achievement Award, which is the highest honor in liposome research. He was the recipient of the 2013 Distinguished Pharmaceutical Scientist Award which is the highest scientific recognition of the American Association of Pharmaceutical Scientists. Dr. Huang has also co-founded 6 biotech start-ups in the past.